業績（論文）

論文

Oiwa K, Watanabe S, Onodera K, Iguchi Y, Kinoshita Y, Komine O, Sobue A, Okada Y, Katsuno M, Yamanaka K Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Sci Adv.9(31):eadf6895.2023 doi: 10.1126/sciadv.adf6895.
Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Shimul RI, Niwa J, Katsuno M, Sobue G, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y* Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling Sci Rep.13(1)8146.2023 doi:10.1038/s41598-023-34445-9
Nakamura R*, Tohnai G*, Nakatochi M*, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa J, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T,Okada Y, Okano H, Sobue G, JaCALS study group Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients J Neurol Neurosurg Psychiatry.jnnp-2022-330851.2023 doi: 10.1136/jnnp-2022-330851.
Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M,Okada Y*, Sobue G*The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK Journal of Neuroscience, 42(47)　8881-8896,　2022 DOI: https://doi.org/10.1523/JNEUROSCI.0455-22.2022*Corresponding authors
Toritsuka M, Yoshino H, Makinodan M, Ikawa D, Kimoto S, Yamamuro K, Okamura K, Akamatsu W, Okada Y, Matsumoto T, Hashimoto K, Ogawa Y, Saito Y, Watanabe K, Aoki C, Takada R, Fukami S, Hamano-Iwasa K, Okano H, Kishimoto T Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons Neurochemistry International (2021) doi: https://doi.org/10.1016/j.neuint.2021.105179.
Taguchi S, Koide H, Oiwa H, Hayashi M, Ogawa K, Ito C , Nakashima K, Yuasa T, Yasumoto A, Ando H, Fujikake A, Fukuoka T, Tokui K, Izumi M, Tsunoda Y, Kawagashira Y, Okada Y, Niwa J, Doyu M Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease PLoS One  2021 Jul 28;16(7):e0255274. doi: 10.1371/journal.pone.0255274. eCollection 2021.
Yamamoto K, Yamaoka N, Imaizumi Y, Nagashima T, Furutani T, Ito T, Okada Y, Honda H, Shimizu K Development of a Human Neuromuscular Tissue-on-a-Chip Model on a 24-Well-Plate-Format Compartmentalized Microfluidic Device Lab on a Chip  2021 May 18;21(10):1897-1907. doi: 10.1039/d1lc00048a.
Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M. Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS Mol Ther Nucleic Acids 2021 Feb 2021.02.007 15;24:1-10 DOI: 10.1016/j.omtn.2021.02.007. eCollection 2021 Jun 4
Koike H, Mouria N, Fukamia Y, Iijima M, Matsuo K, Yagi N, Saito A, Nakamura H, Takahashi K, Nakae Y, Okada Y, Tanaka F, Sobue G, Katsuno M Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis J Neurol Sci 2021 Feb 15; 421: 117305 DOI: 10.1016/j.jns.2020.117305
Okada R, Onodera K, Ito T, Doyu M, Okano HJ, Okada Y* Modulation of oxygen tension, acidosis, and cell density is crucial for neural differentiation of human induced pluripotent stem cells Neurosci. Res 2020.01.015. Epub 2020 Jan 31. 2021 Feb 163:34-42 DOI: 10.1016/j.neures.2020.01.015 (Cover)
Nagashima T, Hadiwidjaja S, Ohsumi S, Murata A, Hisada T, Kato R, Okada Y, Honda H, Shimizu K* In vitro model of human skeletal muscle tissues with contractility fabricated by immortalized human myogenic cells Adv Biosyst 2020 4(11):e2000121 DOI: 10.1002/adbi.202000121
Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Okada Y, Ishihara T, Onodera O, Nakashima K, Kaji R, Kamatani Y, Ikegawa S, Momozawa Y, Kubo M, Ishida N, Minegishi N, Nagasaki M, Sobue G A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis Commun Biol 2020 23;3(1):526 doi: 10.1038/s42003-020-01251-2
Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y* Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs Mol. Brain 2020 13(1):18 DOI: 10.1186/s13041-020-0561-1
Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H Tandem paired nicking promotes precise genome editing with scarce interference by p53 Cell Rep 2020 .2019.12.06 4.30(4):1195-1207.e7 DOI: 10.1016/j.celrep.2019.12.064
Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M, Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy Nat. Commun 2019 10(1): 4262 DOI: 10.1038/s41467-019-12282-7
Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, Kitajima Y, Nishiyama A, Izumi R, Morimoto S, Okada Y, Kamei T, Nishida M, Nogami M, Kaneda S, Ikeuchi Y, Mitsuhashi H, Nakayama K, Fujii T, Warita H, Okano H, Aoki M. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons EBioMedicine 2019.06.013. Epub 2019 Jun 29 45:362-378 doi: 10.1016/j.ebiom
Yamaoka N, Shimizu K, Imaizumi Y, Ito T, Okada Y, Honda H. Open-Chamber Co-Culture Microdevices for single-cell analysis of skeletal muscle myotubes and motor neurons with neuromuscular junctions BioChip Journal 2019 13(2) 127-132 doi: https://doi.org/10.1007/s13206-018-3202-3
Miyawaki S, Okada Y, Okano H, Miura K, Teratoma Formation Assay for Assessing Pluripotency and Tumorigenicity of Pluripotent Stem Cells Bio-protocol 2017 7(16), e2518 doi: https://doi.org/10.21769/BioProtoc.2518
Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G. Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy J Neurol 2017 264(5) 839-847 doi: 10.1007/s00415-017-8405-3
Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, Sobue G Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes Cell Reports 2017 18(5):1118-1131. DOI: 10.1016/j.celrep.2017.01.013